Registered Nurse (RN) Jobs in Sanford, FL

Current registered nurse openings in Sanford, Florida, and a quick look at life there for you and your family. Every listing is open right now; filled and expired jobs are removed automatically.

Sanford is on Lake Monroe about 20 miles north of downtown Orlando, with a historic downtown, a lakefront riverwalk and its own airport. Nurses get Orlando-area jobs and pay with a smaller-town feel and highly rated Seminole County schools.

3 open positionsPosted pay: $63,900 – $110,000Living in Sanford ↓Leer en español

Open positions (3)

RN Cardiac Neuro Tele (Med-Tele Unit) Florida

GalenoMD Healthcare

Sanford, FL$63,900 – $92,900Full-time
RN - Med/SurgOngoing needUpdated 108 days agoDirect Apply Image

CVOR - Advance Cardiovascular Surgery Nursing 80K - 110K Sanford,FL

GalenoMD Healthcare

Sanford, Florida$80,000 – $110,000Fulltime
RN - ICU / Critical CareOngoing needUpdated 173 days agoDirect Apply Image

RN-FL Cardiac Neuro (Stroke Unit) -Sanford, FL

GalenoMD Healthcare

Sanford, FLCompetitive / NegotiableFulltime
Registered Nurse (RN)Ongoing needUpdated 173 days agoDirect Apply

Living in Sanford

What nurses and their families want to know before a move.

Median home value
$309,300
Median rent
$1,760/mo
Orlando metro
Average commute
25 min
Public school district
Grade A
Seminole County Public Schools

Why nurses like Sanford

  • Seminole County schools earned an A from the state in 2025–26.
  • SunRail commuter train connects Sanford to downtown Orlando.
  • Lake Monroe riverwalk, brewery and restaurant scene downtown, and the Central Florida Zoo.

Schools and colleges

Public schools are run by Seminole County Public Schools, which earned an A from the Florida Department of Education for 2025–26. Nearby colleges: Seminole State College, University of Central Florida (Orlando).

Good to know

Rent shown is the Orlando metro median, since the Census city figure was not available; ask our recruiters about current rents in Sanford neighborhoods.

Sources: U.S. Census Bureau, American Community Survey 2020–2024; USAFacts (Census ACS 2020–2024), metro-area rent; Florida Department of Education, 2025–26 district grades.

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Florida RN licensing in brief

  • Florida is a Nurse Licensure Compact state. If your primary residence is another compact state and you hold a multistate license there, you can usually start working in Florida on that license.
  • If you move to Florida, Florida becomes your home state and you apply for a Florida license.
  • Licensed outside the compact (including Puerto Rico)? You can apply to the Florida Board of Nursing for licensure by endorsement. Passing the NCLEX-RN is generally required.
  • Rules change, so confirm current requirements with the Florida Board of Nursing. Our recruiters can walk you through the steps for a specific job.

How applying through GalenoMD works

  • Apply on any listing marked Direct Apply. It takes a few minutes and you can attach your resume.
  • A GalenoMD recruiter reviews your application and contacts you about the role, schedule and pay.
  • Don't see the right job? Submit your resume once and we'll reach out when a match opens up.

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